Zyrig 1000IU Injection is derived from the blood of horses. It neutralizes the virus at the wound site within a few hours. There are two types of Rabies Immunoglobulin (RIG), human (hRIG) and equine (eRIG). Both have similar clinical effectiveness in eliminating the virus at the wound site. Zyrig 1000IU Injection is given as an injection by a doctor or nurse. It is indicated in individuals with category III exposures (in-depth injury). RIG neutralizes the rabies virus at the inoculation site before the immune system responds to the vaccine by the production of rabies virus-neutralizing antibodies. Both active (vaccine) and passive immunization (Immunoglobulin) prevent the rabies virus from infiltrating the central nervous system, but become ineffective once the virus has crossed into the central nervous system. Zyrig 1000IU Injection is administered only once in a lifetime. The most common side effects include nausea, acute toxicity, rash, and stomach upset. They do not normally last very long. Sitting or lying down can sometimes help. Consult your doctor if any of the side effects persist or worry you. Before having the injection, you should tell your doctor if you have ever had an allergic reaction to an immunoglobulin. Some other medicines may react with the equine rabies immunoglobulin so talk to your doctor about other medications you are taking as well. You should consult your doctor first if you are pregnant or breastfeeding.

• Acute toxicity
• Rash
• Upset stomach

If you miss a dose of Zyrig 1000IU Injection, please consult your doctor.

• Q. Q. Is Zyrig 1000IU Injection better than human rabies immunoglobulin??
  Ans: Zyrig 1000IU Injection is more economical as compared to human rabies immunoglobulin (HRIG) and hence more affordable to patients in developing countries, like India. However, Zyrig 1000IU Injection may cause anaphylaxis (a severe, potentially life-threatening allergic reaction), serum sickness and other allergic reactions and thus, physicians are hesitant to use it.
• Q. Q. How effective is Zyrig 1000IU Injection??
  Ans: Rabies is a 100% preventable disease. Proper wound management and simultaneous administration of Zyrig 1000IU Injection combined with anti-rabies vaccine (ARV) is almost invariably effective in preventing rabies, even after high-risk exposure.
• Q. Q. Is Zyrig 1000IU Injection necessary??
  Ans: Zyrig 1000IU Injection is not required for patients who have previously received a complete vaccination series of rabies.
• Q. Q. How do you administer Zyrig 1000IU Injection ??
  Ans: Zyrig 1000IU Injection should be administered into the muscle (the intramuscularly). If a large volume (> 2mL for children or > 5 mL for adults) is required, it is advised to divide the doses and for each dose a different site should be used. The immunoglobulin and the anti-rabies vaccine should be administered at two different sites of the body.
• Q. Q. Is Zyrig 1000IU Injection painful??
  Ans: Whether Zyrig 1000IU Injection is painful or not depends on your pain tolerance. During your initial treatment, a healthcare professional will put Zyrig 1000IU Injection in the area where you were bitten which can be painful. Therefore, you may need a relatively greater amount of Zyrig 1000IU Injection may be required to be placed in and around the wound site to ease out your pain and treat infection.

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