Yondelis Injection is used in the treatment of some kinds of cancers. It is used in patients with advanced soft tissue sarcoma when previous medicines have been unsuccessful. It is also used with other medicines as part of combination therapy to treat ovarian cancer that has come back. Yondelis Injection is given as an injection under the medical supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include headache, fatigue, vomiting, weakness and increased liver enzyme. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver and kidney. Generally, avoid alcohol consumption while on treatment. Before taking it, tell your doctor if have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using.This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy.

• Fatigue
• Vomiting
• Weakness
• Nausea
• Increased liver enzymes
• Low blood platelets
• Increased creatine phosphokinase (CPK) level in blood
• Decreased white blood cell count (neutrophils)
• Decreased appetite
• Constipation

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