Pisi Injection is a pain-relieving medicine. It is used in the treatment of moderate to severe pain. It helps to relieve pain and swelling of various conditions related to joints and muscles. It is usually given in cases where oral administration is unsuitable. Pisi Injection is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep receiving the medicine until the doctor says it is okay to stop using the medicine. The most common side effects of this medicine include injection site reactions (such as pain, redness, and swelling), vomiting, stomach pain, indigestion, diarrhea, headache, and dizziness. If any of these side effects persist or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms. Before using it, you should let your doctor know if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine. This medicine is not recommended for pregnant or breastfeeding women. Pregnant and breastfeeding mothers must consult with their doctors before using the medicine. Your doctor may also regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment.

• Vomiting
• Stomach pain
• Nausea
• Headache
• Dizziness

If you miss a dose of Pisi Injection, consult your doctor.

• Q. Q. What is the difference between Pisi Injection and diclofenac??
  Ans: Both Pisi Injection and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Pisi Injection.
• Q. Q. What is the difference between Pisi Injection and naproxen??
  Ans: Both Pisi Injection and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Pisi Injection.
• Q. Q. What is the difference between Pisi Injection and meloxicam??
  Ans: Both Pisi Injection and meloxicam are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, acute gastric side effects are lesser with meloxicam as compared to Pisi Injection.
• Q. Q. What is the difference between Pisi Injection and ketoprofen??
  Ans: Both Pisi Injection and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to Pisi Injection. Ketoprofen gel also showed excellent tolerability.
• Q. Q. What is the difference between Pisi Injection and tramadol??
  Ans: Pisi Injection is a COX (cyclooxygenase -an enzyme responsible for inflammation and pain) whereas Tramadol is a narcotic-like painkiller. Tramadol is a habit forming medicine.
• Q. Q. What is the difference between Pisi Injection and nimesulide??
  Ans: Both Pisi Injection and nimesulide are pain killers. However, Pisi Injection is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.
• Q. Q. Can Pisi Injection be used in the treatment of chikungunya??
  Ans: Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Pisi Injection or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Pisi Injection.
• Q. Q. Are Pisi Injection and aspirin same??
  Ans: No. Pisi Injection and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.
• Q. Q. Can Pisi Injection be used along with dexamethasone??
  Ans: No. Pisi Injection should not be used with dexamethasone. They both increase each other's toxicity. There is an increased risk of GI ulceration.
• Q. Q. Can Pisi Injection be used with methocarbamol??
  Ans: Yes. Methocarbamol can be used with Pisi Injection as no serious side effects are known. Inform your doctor before starting any of the medication.
• Q. Q. Can Pisi Injection be used along with paracetamol??
  Ans: Yes. Paracetamol can be used with Pisi Injection as no serious side effects are known. Inform your doctor before starting any of the medication.
• Q. Q. Is Pisi Injection a NSAID??
  Ans: Yes. Pisi Injection is a non-steroidal anti-inflammatory drug (NSAID).
• Q. Q. Is Pisi Injection a sulfa drug??
  Ans: Pisi Injection is a sulphur containing compound. Pisi Injection can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.
• Q. Q. Is Pisi Injection a blood thinner??
  Ans: No. Pisi Injection is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.
• Q. Q. Is Pisi Injection a muscle relaxant??
  Ans: No. Pisi Injection is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.
• Q. Q. Is Pisi Injection a narcotic??
  Ans: No. Pisi Injection is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.
• Q. Q. Can Pisi Injection be used in hypertension??
  Ans: No. Pisi Injection is not a medication to control hypertension. It is important to note that Pisi Injection decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting Pisi Injection.
• Q. Q. Can Pisi Injection be used along with Losartan??
  Ans: No. Pisi Injection should not be combined with Losartan. It is important to note that Pisi Injection decreases the effectiveness of the antihypertensive medication like losartan when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Pisi Injection.
• Q. Q. Can Pisi Injection be used with Lisinopril??
  Ans: No. Pisi Injection should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Pisi Injection.
• Q. Q. Can Pisi Injection be used with calcium channel blocker??
  Ans: Yes. Pisi Injection can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)
• Q. Q. Can Pisi Injection be used with Tizanidine??
  Ans: Yes, Pisi Injection can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.
• Q. Q. Why is beta cyclodextrin added to Pisi Injection??
  Ans: Yes. Pisi Injection can be combined with beta-cyclodextrin. Research has shown that combining Pisi Injection with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.
• Q. Q. Are there any alternatives of Pisi Injection??
  Ans: Yes. There are alternatives to Pisi Injection. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.
• Q. Q. What are the contraindications for Pisi Injection??
  Ans: Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.
• Q. Q. Can Pisi Injection be used in the treatment of allergy??
  Ans: No. Pisi Injection is not a drug to treat allergy. It is a pain killer.
• Q. Q. How long does Pisi Injection work??
  Ans: Pisi Injection is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.
• Q. Q. Can you get high by using Pisi Injection??
  Ans: No. Pisi Injection is not known to cause high. It is a non-narcotic painkiller.
• Q. Q. Can Pisi Injection be used to treat menstrual cramp??
  Ans: Pisi Injection is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.
• Q. Q. Can I use Pisi Injection for a migraine??
  Ans: Pisi Injection is not approved for the treatment of migraine. Research studies have shown that Pisi Injection is effective in significantly decreasing the pain associated with migraine without aura.
• Q. Q. Is Pisi Injection effective in back pain management??
  Ans: Yes. It can be given for decreasing the back pain. However, you should consult your doctor for the exact cause of your back pain and then start the treatment. Do not self-medicate yourself with Pisi Injection as the cause of back pain can be different for different person.
• Q. Q. Is Pisi Injection affective in gout management??
  Ans: Yes. Pisi Injection can be given for the treatment of acute gout. Research studies have shown Pisi Injection to be highly effective in the treatment of acute gout.
• Q. Q. Can you donate blood when on the medication with Pisi Injection??
  Ans: Yes. You can donate blood when on Pisi Injection. Do inform your doctor before donating blood.
• Q. Q. Can I use Pisi Injection if I am a diabetic??
  Ans: Pisi Injection in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Pisi Injection so taking piroxicam can lead to increased risk of renal failure by many folds.
• Q. Q. Can I use Pisi Injection if I have a deranged renal function??
  Ans: No. Pisi Injection should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.
• Q. Q. Can Pisi Injection lead to skin reactions??
  Ans: Yes. Pisi Injection is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.
• Q. Q. Can I use Pisi Injection if I am pregnant??
  Ans: No. Pisi Injection should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.
• Q. Q. Can I use Pisi Injection if I have peptic ulcer disease??
  Ans: No. Pisi Injection is contraindicated in cases of active peptic ulcer disease. Pisi Injection is known to cause gastric ulceration and bleeding.
• Q. Q. Can I use Pisi Injection if I have asthma??
  Ans: Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.
• Q. Q. Can Pisi Injection lead to difficulty in conception??
  Ans: Yes. Pisi Injection can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.
• Q. Q. Can Pisi Injection be used with diuretics??
  Ans: No. Pisi Injection should not be used with diuretics. Pisi Injection reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.
• Q. Q. Can Pisi Injection be used with lithium??
  Ans: No. Pisi Injection should not be used with lithium. Pisi Injection leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.
• Q. Q. Can Pisi Injection be used with warfarin??
  Ans: No. Pisi Injection should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.
• Q. Q. What increases the chances of getting a gastric ulcer when I am already taking Pisi Injection??
  Ans: The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.
• Q. Q. Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)/ Pisi Injection??
  Ans: Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.
• Q. Q. What are the serious side effects of Pisi Injection??
  Ans: GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.

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